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Oliva offers advanced hair loss treatments in Hyderabad, Bangalore, Chennai, Kolkata, Pune, Vizag and Kochi. Dutasteride and Finasteride are recommended by dermato-trichologists for patients suffering from heavy hair fall. It is available as a generic medication and it is used primarily to treat enlarged prostate in men. The International Society of Hair Restoration Surgery (ISHRS) is a global non-profit medical association and the leading authority on hair loss treatment and restoration. Dutasteride and finasteride are the primary dihydrotestosterone (DHT) blockers used to treat hair loss.
Side effects of dutasteride and finasteride
Dr. Bauman is happy to discuss the pros and cons of dutasteride with any patient. He often prescribes dutasteride in oral, topical, or mesotherapy formats to his patients. He prefers to prescribe quality compounded oral dutasteride rather than generic forms of the medication. Because of the long half-life, it could take a month or longer for levels of dutasteride in your blood to drop.
Associated Data
Selected studies comprised a total of 1,627 patients, including 480 participants in the placebo group and 1,147 in the active treatment groups. Out of the 1,627 patients included in the analysis, 987 were receiving oral dutasteride and 160 intralesional administration. Characteristics of the included clinical trials are shown in Table Table11. The index date was defined as the first prescription of dutasteride or finasteride, as recorded in medical charts, among patients with a confirmed AGA diagnosis.
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Broken capsules must not be handled by pregnant women, as the active ingredient can be absorbed through the skin and can cause birth defects in male babies. This is because dutasteride can be carried in semen and it could affect the normal development of a male baby. Whether you decide to use dutasteride or not, Pimstone says one of the most important things when it comes to preventing hair loss is treating it early. “With this extensive clinical experience, we are not aware of any serious adverse reactions that have highlighted significant risks with oral formulations,” he concludes.
What are common causes of hair loss?
The lower proportions observed here may be because sexual AEs are not recorded by dermatologists in the real world in the same way as in clinical trials. SAEs were reported infrequently and were equivalent between treatment groups, consistent with the South Korean post-marketing surveillance study, which found SAEs occurred among 0.6% of dutasteride-treated patients15. Our study supports a similar or potentially slightly better safety profile of dutasteride compared with finasteride. Dutasteride is a potent 5AR 5-alpha reductase enzyme inhibitor (blocker) and therefore suppresses the production of DHT dihydrotestosterone, a key trigger for male AGA Androgenetic Alopecia aka Male Pattern Hair Loss. Currently, oral dutasteride has been approved only in Japan (in 2015) and South Korea (in 2010) for male AGA and is not approved by the US FDA for the treatment of male pattern hair loss. Oral dutasteride 0.5mg (Avodart) was approved by the FDA in 2001 for the treatment of BPH benign prostatic hypertrophy or prostate enlargement in men.
Study Design
Before taking palmetto or other dietary supplements while taking dutasteride or finasteride, please consult a healthcare provider to ensure it is safe. As such, when it comes to hair loss, finasteride is backed by more extensive clinical evidence than dutasteride for this purpose. In clinical trials, dutasteride made the prostate 25% smaller, while finasteride made it 18% smaller. These size reductions helped improve urine flow (2.2 milliliters [mL] per second improvement with dutasteride and 1.7 milliliters per second with finasteride).
Dutasteride user reviews
The baseline period was the 6 month-period prior to the index date, during which the inclusion and exclusion criteria were applied. The observation period spanned from the index date until death, loss to follow-up, or data cut-off date, whichever occurred first. Patient demographics and clinical characteristics were assessed during the baseline period. Treatment patterns, effectiveness and safety data were assessed during the observation period. Dutasteride has been shown to provide a greater and more consistent reduction in DHT than finasteride by blocking or inhibiting the action of Type-1, Type-2, and Type-3 5AR enzyme isotypes. Therefore dutasteride is considered by many to be the strongest drug available to treat male pattern hair loss.
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(2) Overall, dutasteride is thought to be a safe and highly effective hair loss treatment. Although statistically rare, the most commonly reported side effects of dutasteride include sexual dysfunction, breast tenderness, and depression. Side effects from oral dutasteride can be avoided by using topical dutasteride (Formula 82D) or Dutasteride Mesotherapy. Switching from finasteride to dutasteride is something you should discuss with your Hair Restoration Physician. Because of the different pharmacokinetics and pharmacodynamics of dutasteride compared to finasteride, your physician may recommend overlapping the two medications for some time while levels of dutasteride build up in your system.
In a clinical study of men at increased risk of prostate cancer, men taking dutasteride were shown to have a serious form of prostate cancer more often than men who weren’t taking the medicine. The study also showed that dutasteride reduced the incidence of prostate cancer for less serious tumours. The good news is, when it comes to hair loss, dutasteride has shown promising clinical effectiveness, is generally safe for use, and is now more accessible than ever. It’s also important to note that dutasteride is not FDA-approved as a hair loss treatment so you’ll need to exercise extra caution if using it for this purpose.
Here at Strut Health, our doctors are familiar with Dutasteride oral and topical formulations for men. You can have a free online questionnaire and picture-based consultation to see if Dutasteride is a good fit for you. If you are interested in seeing if Dutasteride off-label for hair loss is a good option for you, start with talking to your doctor. However, since this is an off-label indication, we do not have many studies that will help doctors conclusively determine the best dose and schedule of Dutasteride to use for the best hair benefits.
It is available over the counter and has been shown to be effective in both men and women. However, as with any medication, it's important to consult with a healthcare provider to determine whether finasteride is right for you and to discuss potential side effects and risks. By inhibiting this conversion process, dutasteride can reduce the levels of DHT in the body, thus slowing down or reversing hair loss.
Although dutasteride for hair loss it isn’t yet approved in many countries, it’s widely used off-label with positive results. (6) Regardless of the form you choose to get dutasteride in, you should be aware that you’ll likely need a prescription from your doctor to obtain this medication. Dutasteride is also sold under the names Combodart and Duodart when combined with the drug tamsulosin in the same medication. When combined, oral dutasteride-tamsulosin treats BPH with very positive results. A Forest plot displaying the difference in proportions and 95% confidence intervals for the libido adverse events at pre- and post-oral dutasteride treatment.
Our meta-analysis involved three RCTs and the quality of each RCT was high. We could not infer the long-term efficacy and tolerance of dutasteride and finasteride, and selection bias and publication bias may affect the final results of our study. So, it still needs a lot of substitution of head-to-head comparison to confirm our findings. More high-quality RCTs with suitable study cohorts are needed to ascertain the efficacy and tolerance of dutasteride and finasteride for the treatment of AGA. Randomized controlled trials of dutasteride and finasteride for treating AGA were searched using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. A person should inform a doctor of any allergies they have, any medications they are taking, and medical conditions they have, such as liver disease or prostate cancer.
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